Bioidentical estrogen cream (50% estriol + 50% estradiol) applied to the skin daily. In the ELITE trial (Hodis et al., NEJM 2016), women who started estrogen within 6 years of menopause had measurably less wall thickening in their carotid arteries over 5 years than women on placebo.
Start Free AssessmentStarting at $55/month if prescribed. No commitment required.
Advanced hormone therapy for targeted treatment and optimization.
binds ER-alpha and ER-beta
Reduced atherosclerosis progression when started within 6 years of menopause
daily
Prescribed after licensed provider review
Phase 3 results demonstrating efficacy and safety.
Phase 3 data — Harman et al., NEJM 2014. Bi-Est 50:50 Cream demonstrates significant clinical efficacy.
Mechanism of Action
binds ER-alpha and ER-beta
Bioidentical estrogen (estriol + estradiol) — binds ER-alpha and ER-beta
Based on clinical evidence, Reduced atherosclerosis progression when started within 6 years of menopause. Individual results vary.
Bi-Est 50:50 Cream is administered daily. Your shipment includes detailed instructions.
The most common side effects include Breast tenderness, Spotting, Bloating. Contact our care team if you experience concerning symptoms.
Take our free eligibility check. Our physicians review your health history to determine if Bi-Est 50:50 Cream is appropriate.